Translating Light-Sheet Microscopy Images to Virtual H&E Using CycleGAN

Histopathology analysis relies on Hematoxylin and Eosin (H&E) staining, but fluorescence microscopy offers complementary information. Converting fluorescence images to H&E-like appearance can aid interpretation and integration with standard workflows. We present a Cycle-Consistent Adversarial Network (CycleGAN) approach for unpaired image-to-image translation from multi-channel fluorescence microscopy to pseudo H&E stained histopathology images. The method combines C01 and C02 fluorescence channels into RGB and learns a bidirectional mapping between fluorescence and H&E domains without paired training data. The architecture uses ResNet-based generators with residual blocks and PatchGAN discriminators, trained with adversarial, cycle-consistency, and identity losses. Experiments on fluorescence microscopy datasets show the model generates realistic pseudo H&E images that preserve morphological structures while adopting H&E-like color characteristics. This enables visualization of fluorescence data in a format familiar to pathologists and supports integration with existing H&E-based analysis pipelines.

Language-Grounded Multi-Domain Image Translation via Semantic Difference Guidance

Multi-domain image-to-image translation re quires grounding semantic differences ex pressed in natural language prompts into corresponding visual transformations, while preserving unrelated structural and seman tic content. Existing methods struggle to maintain structural integrity and provide fine grained, attribute-specific control, especially when multiple domains are involved. We propose LACE (Language-grounded Attribute Controllable Translation), built on two compo nents: (1) a GLIP-Adapter that fuses global semantics with local structural features to pre serve consistency, and (2) a Multi-Domain Control Guidance mechanism that explicitly grounds the semantic delta between source and target prompts into per-attribute translation vec tors, aligning linguistic semantics with domain level visual changes. Together, these modules enable compositional multi-domain control with independent strength modulation for each attribute. Experiments on CelebA(Dialog) and BDD100K demonstrate that LACE achieves high visual fidelity, structural preservation, and interpretable domain-specific control, surpass ing prior baselines. This positions LACE as a cross-modal content generation framework bridging language semantics and controllable visual translation.

When Humans Judge Irises: Pupil Size Normalization as an Aid and Synthetic Irises as a Challenge

Iris recognition is a mature biometric technology offering remarkable precision and speed, and allowing for large-scale deployments to populations exceeding a billion enrolled users (e.g., AADHAAR in India). However, in forensic applications, a human expert may be needed to review and confirm a positive identification before an iris matching result can be presented as evidence in court, especially in cases where processed samples are degraded (e.g., in post-mortem cases) or where there is a need to judge whether the sample is authentic, rather than a result of a presentation attack. This paper presents a study that examines human performance in iris verification in two controlled scenarios: (a) under varying pupil sizes, with and without a linear/nonlinear alignment of the pupil size between compared images, and (b) when both genuine and impostor iris image pairs are synthetically generated. The results demonstrate that pupil size normalization carried out by a modern autoencoder-based identity-preserving image-to-image translation model significantly improves verification accuracy. Participants were also able to determine whether iris pairs corresponded to the same or different eyes when both images were either authentic or synthetic. However, accuracy declined when subjects were comparing authentic irises against high-quality, same-eye synthetic counterparts. These findings (a) demonstrate the importance of pupil-size alignment for iris matching tasks in which humans are involved, and (b) indicate that despite the high fidelity of modern generative models, same-eye synthetic iris images are more often judged by humans as different-eye images, compared to same-eye authentic image pairs. We offer data and human judgments along with this paper to allow full replicability of this study and future works.

OSCAR: Optical-aware Semantic Control for Aleatoric Refinement in Sar-to-Optical Translation

Synthetic Aperture Radar (SAR) provides robust all-weather imaging capabilities; however, translating SAR observations into photo-realistic optical images remains a fundamentally ill-posed problem. Current approaches are often hindered by the inherent speckle noise and geometric distortions of SAR data, which frequently result in semantic misinterpretation, ambiguous texture synthesis, and structural hallucinations. To address these limitations, a novel SAR-to-Optical (S2O) translation framework is proposed, integrating three core technical contributions: (i) Cross-Modal Semantic Alignment, which establishes an Optical-Aware SAR Encoder by distilling robust semantic priors from an Optical Teacher into a SAR Student (ii) Semantically-Grounded Generative Guidance, realized by a Semantically-Grounded ControlNet that integrates class-aware text prompts for global context with hierarchical visual prompts for local spatial guidance; and (iii) an Uncertainty-Aware Objective, which explicitly models aleatoric uncertainty to dynamically modulate the reconstruction focus, effectively mitigating artifacts caused by speckle-induced ambiguity. Extensive experiments demonstrate that the proposed method achieves superior perceptual quality and semantic consistency compared to state-of-the-art approaches.

SRU-Pix2Pix: A Fusion-Driven Generator Network for Medical Image Translation with Few-Shot Learning

Magnetic Resonance Imaging (MRI) provides detailed tissue information, but its clinical application is limited by long acquisition time, high cost, and restricted resolution. Image translation has recently gained attention as a strategy to address these limitations. Although Pix2Pix has been widely applied in medical image translation, its potential has not been fully explored. In this study, we propose an enhanced Pix2Pix framework that integrates Squeeze-and-Excitation Residual Networks (SEResNet) and U-Net++ to improve image generation quality and structural fidelity. SEResNet strengthens critical feature representation through channel attention, while U-Net++ enhances multi-scale feature fusion. A simplified PatchGAN discriminator further stabilizes training and refines local anatomical realism. Experimental results demonstrate that under few-shot conditions with fewer than 500 images, the proposed method achieves consistent structural fidelity and superior image quality across multiple intra-modality MRI translation tasks, showing strong generalization ability. These results suggest an effective extension of Pix2Pix for medical image translation.

Imaging-anchored Multiomics in Cardiovascular Disease: Integrating Cardiac Imaging, Bulk, Single-cell, and Spatial Transcriptomics

Cardiovascular disease arises from interactions between inherited risk, molecular programmes, and tissue-scale remodelling that are observed clinically through imaging. Health systems now routinely generate large volumes of cardiac MRI, CT and echocardiography together with bulk, single-cell and spatial transcriptomics, yet these data are still analysed in separate pipelines. This review examines joint representations that link cardiac imaging phenotypes to transcriptomic and spatially resolved molecular states. An imaging-anchored perspective is adopted in which echocardiography, cardiac MRI and CT define a spatial phenotype of the heart, and bulk, single-cell and spatial transcriptomics provide cell-type- and location-specific molecular context. The biological and technical characteristics of these modalities are first summarised, and representation-learning strategies for each are outlined. Multimodal fusion approaches are reviewed, with emphasis on handling missing data, limited sample size, and batch effects. Finally, integrative pipelines for radiogenomics, spatial molecular alignment, and image-based prediction of gene expression are discussed, together with common failure modes, practical considerations, and open challenges. Spatial multiomics of human myocardium and atherosclerotic plaque, single-cell and spatial foundation models, and multimodal medical foundation models are collectively bringing imaging-anchored multiomics closer to large-scale cardiovascular translation.

From Rays to Projections: Better Inputs for Feed-Forward View Synthesis

Feed-forward view synthesis models predict a novel view in a single pass with minimal 3D inductive bias. Existing works encode cameras as Plücker ray maps, which tie predictions to the arbitrary world coordinate gauge and make them sensitive to small camera transformations, thereby undermining geometric consistency. In this paper, we ask what inputs best condition a model for robust and consistent view synthesis. We propose projective conditioning, which replaces raw camera parameters with a target-view projective cue that provides a stable 2D input. This reframes the task from a brittle geometric regression problem in ray space to a well-conditioned target-view image-to-image translation problem. Additionally, we introduce a masked autoencoding pretraining strategy tailored to this cue, enabling the use of large-scale uncalibrated data for pretraining. Our method shows improved fidelity and stronger cross-view consistency compared to ray-conditioned baselines on our view-consistency benchmark. It also achieves state-of-the-art quality on standard novel view synthesis benchmarks.

Illumination Angular Spectrum Encoding for Controlling the Functionality of Diffractive Networks

Diffractive neural networks have recently emerged as a promising framework for all-optical computing. However, these networks are typically trained for a single task, limiting their potential adoption in systems requiring multiple functionalities. Existing approaches to achieving multi-task functionality either modify the mechanical configuration of the network per task or use a different illumination wavelength or polarization state for each task. In this work, we propose a new control mechanism, which is based on the illumination's angular spectrum. Specifically, we shape the illumination using an amplitude mask that selectively controls its angular spectrum. We employ different illumination masks for achieving different network functionalities, so that the mask serves as a unique task encoder. Interestingly, we show that effective control can be achieved over a very narrow angular range, within the paraxial regime. We numerically illustrate the proposed approach by training a single diffractive network to perform multiple image-to-image translation tasks. In particular, we demonstrate translating handwritten digits into typeset digits of different values, and translating handwritten English letters into typeset numbers and typeset Greek letters, where the type of the output is determined by the illumination's angular components. As we show, the proposed framework can work under different coherence conditions, and can be combined with existing control strategies, such as different wavelengths. Our results establish the illumination angular spectrum as a powerful degree of freedom for controlling diffractive networks, enabling a scalable and versatile framework for multi-task all-optical computing.

Few-Shot LoRA Adaptation of a Flow-Matching Foundation Model for Cross-Spectral Object Detection

Foundation models for vision are predominantly trained on RGB data, while many safety-critical applications rely on non-visible modalities such as infrared (IR) and synthetic aperture radar (SAR). We study whether a single flow-matching foundation model pre-trained primarily on RGB images can be repurposed as a cross-spectral translator using only a few co-measured examples, and whether the resulting synthetic data can enhance downstream detection. Starting from FLUX.1 Kontext, we insert low-rank adaptation (LoRA) modules and fine-tune them on just 100 paired images per domain for two settings: RGB to IR on the KAIST dataset and RGB to SAR on the M4-SAR dataset. The adapted model translates RGB images into pixel-aligned IR/SAR, enabling us to reuse existing bounding boxes and train object detection models purely in the target modality. Across a grid of LoRA hyperparameters, we find that LPIPS computed on only 50 held-out pairs is a strong proxy for downstream performance: lower LPIPS consistently predicts higher mAP for YOLOv11n on both IR and SAR, and for DETR on KAIST IR test data. Using the best LPIPS-selected LoRA adapter, synthetic IR from external RGB datasets (LLVIP, FLIR ADAS) improves KAIST IR pedestrian detection, and synthetic SAR significantly boosts infrastructure detection on M4-SAR when combined with limited real SAR. Our results suggest that few-shot LoRA adaptation of flow-matching foundation models is a promising path toward foundation-style support for non-visible modalities.

Edit2Restore:Few-Shot Image Restoration via Parameter-Efficient Adaptation of Pre-trained Editing Models

Image restoration has traditionally required training specialized models on thousands of paired examples per degradation type. We challenge this paradigm by demonstrating that powerful pre-trained text-conditioned image editing models can be efficiently adapted for multiple restoration tasks through parameter-efficient fine-tuning with remarkably few examples. Our approach fine-tunes LoRA adapters on FLUX.1 Kontext, a state-of-the-art 12B parameter flow matching model for image-to-image translation, using only 16-128 paired images per task, guided by simple text prompts that specify the restoration operation. Unlike existing methods that train specialized restoration networks from scratch with thousands of samples, we leverage the rich visual priors already encoded in large-scale pre-trained editing models, dramatically reducing data requirements while maintaining high perceptual quality. A single unified LoRA adapter, conditioned on task-specific text prompts, effectively handles multiple degradations including denoising, deraining, and dehazing. Through comprehensive ablation studies, we analyze: (i) the impact of training set size on restoration quality, (ii) trade-offs between task-specific versus unified multi-task adapters, (iii) the role of text encoder fine-tuning, and (iv) zero-shot baseline performance. While our method prioritizes perceptual quality over pixel-perfect reconstruction metrics like PSNR/SSIM, our results demonstrate that pre-trained image editing models, when properly adapted, offer a compelling and data-efficient alternative to traditional image restoration approaches, opening new avenues for few-shot, prompt-guided image enhancement. The code to reproduce our results are available at: https://github.com/makinyilmaz/Edit2Restore